What Are The Target Organ Of Vinyl Chloride

Target organs liver central nervous system blood respiratory system lymphatic system cancer site liver cancer.

What are the target organ of vinyl chloride.

Additional research has now demonstrated the carcinogenicity of vc to other organs and at lower concentrations. Box 24440 doha state of qatar. The liver appears to be the most sensitive target organ of vinyl chloride. Vinyl chloride is thought to depress the cns via a solvent effect on lipids and protein components of neural membranes that interrupt signal transmission.

Accidental ingestion may be possible when eating or smoking with contaminated hands. Target organ effect the target organs and potential effects of vinyl chloride exposure include. At room temperature vinyl chloride is a colorless highly flammable potentially explosive gas. Table 1 target organs and potential effects of vinyl chloride exposure target organ effect.

Occupational exposure to vinyl chloride has been associated with reduced sexual function in both sexes and gynecological effects in women makarov 1984. Target organ toxins are chemicals that can cause adverse effects or disease states manifested in specific organs of the body. The reader is referred to section 3 2 discussion of health effects by route of exposure for additional information on other effects. It is shipped and handled this way.

The target organs for vc now clearly in. 12 10 2017 01 identification of the substance preparation and the company undertaking product name vinyl chloride monomer sds no. Synonyms trade names chloroethene chloroethylene ethylene monochloride monochloroethene monochloroethylene vc vcm vinyl chloride monomer vcm. Toxins do not affect all organs in the body to the same extent due to their different cell structures.

003 manufacturer emergency telephone no. The odor threshold for vinyl chloride is about 3 000 ppm in air depending on the individual. Vinyl chloride is an organochloride with the formula h 2 c chcl that is also called vinyl chloride monomer vcm or chloroethene this colorless compound is an important industrial chemical chiefly used to produce the polymer polyvinyl chloride pvc. It has a faint sweet odor.

About 13 billion kilograms are produced annually. The following is a target organ categorization of effects which may occur from exposure to hazardous chemicals including examples of signs and symptoms and. Makarov et al 1984. The cns is the primary target of vinyl chloride acute toxicity.

For the oral route of exposure the primary target organ of vinyl chloride toxicity in animals is the liver. Vinyl chloride monomer page 1 of 8 sds no. In 1974 vinyl chloride vc was first reported in the open scientific literature to induce angiosarcoma of the liver both in humans and in animals. When confined under high pressure in special containers vinyl chloride exists in a liquefied state.

Noncancerous hepatotoxicity and carcinogenicity of vinyl chloride are discussed in greater detail below.