What Is Lamin A C

Lmna also known as lamin a c is a protein that in humans is encoded by the lmna gene.

What is lamin a c.

Lamin c is a splice variant of lamin a differing only at the carboxy terminus. The lamins are components of the nuclear lamina a fibrous layer on the nucleoplasmic side of the inner nuclear membrane which is suggested to provide a framework for the nuclear envelope and may interact with chromatin. Nuclear lamins a b1 b2 and c. Haplo insufficiency in the cardiomyocyte nuclei.

Unlike lamin c lamin a is generated in a precursor form called prelamin a. 290 the transcript from the gene is spliced differentially to give rise to the two different forms lamin a and lamin c. Prelamin a and lamin c differ in structure only at the carboxyl terminus. Lamin a c belongs to the lamin family of proteins.

Not intended for diagnostic or therapeutic use. The cleavage of lamins results in nuclear dysregulation and cell death 5 6. Biogenesis of lamin a in normal cells and the failure to generate mature lamin a in hutchinson gilford progeria. The cleavage of lamins results in nuclear dysregulation and cell death 5 6.

This creates a high amount of homology between the isoforms. Lamins a and c are identical for the first 566 amino acids with lamin c differing only in six unique carboxy terminal amino acids. During apoptosis lamin a c is specifically cleaved into a large 41 50 kda and a small 28 kda fragment 3 4. Lamin a c is an intermediate filament lining the inner nuclear membrane part of the nuclear envelope.

Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation. Lamin a was detected in 10 to 20 of hgps lymphocytes. Western blot analysis showed 25 of normal lamin a levels and no truncated form was detected. Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation.

Lamin a c expression explored in various explanted heart tissues from patients carrying nonsense lmna mutations revealed reduced lamin a c level i e. Lamin c does not have to undergo this processing before becoming part of the lamina. The lamin a protein must be processed within the cell before becoming part of the lamina. Its initial form called prelamin a undergoes a complex series of steps that are necessary for the protein to be inserted into the lamina.

Lamin a c is a type v nuclear lamin. Only lamin c was present in most cells and lamin b1 was found in the nucleoplasm suggesting that it had dissociated from the nuclear envelope due to the loss of lamin a. Two isoforms lamins a and c can be created from this gene via alternative splicing.